Ferdowsi’s knowledge-based nano-biotechnology company managed by Dr. Maria Bayhaghi succeeded in making money

Silver medal in the 3rd Swiss International Competition of Inventions and Innovations 2023 for the invention

Medicinal products based on human and plant exosomes have been developed for skin diseases

Patent entitled “Production of complementary medicine for air and Alzheimer’s treatment based on herbal nanoparticles of fencol and

Querstein” under the supervision of Dr. Maria Bayhaghi (a faculty member of the Kavian Institute of Higher Education) and an official member

International Federation of Swiss Inventors (ifia), in international competitions for special Swiss inventions and innovations

The members of the World Federation of Inventors won the gold medal

This success is due to Mrs. Beyhaqi, the CEO of Ferdowsi Nano Biotechnology Company, from the units

Congratulations to Ferdowsi University of Mashhad science and technology park technologist

Production of anti-Alzheimer’s gum, candies and pastilles with two nanomaterials

The joint project of Mashhad University of Medical Sciences (Health Science and Technology Park and Bo Ali Research Institute) and Ferdowsi University led to the production of a nano supplement for the prevention and treatment of Alzheimer’s disease, and according to them, people with a history of Alzheimer’s disease in their families can use it to prevent the occurrence of this disease. Use this nano supplement

According to the General Department of Public Relations and International Affairs of the National Pension Fund, quoted by Isna, one person in the world is diagnosed with dementia every 3 seconds, the cost of dementia in the world in 2018 was one trillion dollars, and dementia is the seventh cause of death in the world. The world is considered

This is despite the fact that most countries in the world lack diagnostic tools – clinical tests and the number of specialist doctors and researchers is small

The results of the research conducted on the prevalence of dementia in the country, which was published in 2012 (2012) by Sharifi and colleagues in Iran’s Journal of Endocrine and Metabolism, in 109 health centers in 63 cities located in five provinces of West Azarbaijan, North Khorasan, Sistan and Baluchistan, Khuzestan and Alborz were conducted and their average age in this study was 69.2 years, women were 52.9% and men were 47.1%

According to this study, the highest rate of diagnosis was in Alborz province with 40% and the lowest in Khuzestan which was 9.7%. The detection rate was almost the same in men and women.

This means that under normal conditions and without special screening, only about 20% of existing dementia cases could be identified and diagnosed

Among the reasons for not diagnosing dementia are the nature and manifestations of the disease, lack of awareness among the general population, and lack of skills of doctors and other people involved in the health field. This is a global problem, for example, in England, the diagnosis rate of people with dementia is not more than 45%.

Despite the higher prevalence of dementia in women, the detection rate is usually lower in women, which means that it is more difficult to diagnose the disorder in women

Based on this, the researcher of Ferdowsi University of Mashhad and Mashhad Medical Sciences, in collaboration with Dr. Mehdi Mirahmadi, implemented a joint project in this field and were able to use two nanoparticles as a complementary medicine in the form of chewing gum and candy, and recently syrup to prevent and reduce the symptoms of Alzheimer’s disease. and according to them, its pastel form will be produced soon.

Dr. Maria Bayhaghi, one of the researchers of Ferdowsi University and Boali Research Institute of Mashhad University of Medical Sciences and the project manager, said: In this joint project, we have produced a pharmaceutical supplement for the prevention and treatment of Alzheimer’s, which has also been patented, and after completing the clinical phases, in The production phase is located

Stating that this complementary medicine is produced in the form of candy and chewing gum, he said: “Production of this medicine in the form of syrup is also on our agenda”

Saying that this drug is produced in the form of nanoparticles, Bayhaghi continued: This drug based on nanoparticles contains natural products of nanoparticles “Fencol” and “Quercetin” which, in addition to treating and preventing Alzheimer’s, can prevent oral cancers. esophagus and stomach, eliminating cancer cells, improving allergy symptoms, reducing inflammation and releasing histamine compounds in allergic reactions, controlling blood sugar, preventing infection, preventing neurological diseases and helping to prevent heart diseases and reducing high blood pressure, increasing It helps the body’s immune system and reduces skin irritation

Referring to the formulation of this drug, emphasizing that an effective plant substance was used for the production of this drug, he pointed out: two effective substances of this drug, namely “fencol” and “quercetin”, were formulated in nano form and this formulation In the first step, it was used to produce medicine in the form of chewing gum and candy, but since these medicines are mostly prescribed for the elderly, we turned this formulation into syrup, which has therapeutic properties

Saying that this complementary medicine is used for the prevention and treatment of Alzheimer’s, Beyhaghi reminded: In the clinical trial phase, we studied 30 people with Alzheimer’s disease, and these people had behavioral movements, behavioral and nervous tensions, and sufficient sleep. They didn’t have and by taking this medicine, these movements improved

This researcher of Ferdowsi University of Mashhad stated that this drug is also a strong antioxidant drug and said: The results of clinical tests showed that by taking this drug, the tremors of the hands of Parkinson’s patients improved, while their nervous and behavioral behaviors also decreased

He stated that this drug should be used as a complementary drug along with the drugs prescribed by doctors, and said: The use of this drug has also increased the effectiveness of drugs for Alzheimer’s patients

Drug efficacy for prevention and treatment of Alzheimer’s

Bayhaghi explained the function of this drug in the body and said: The two nanoparticles used in this drug inhibit the expression of a group of genes, from the age of 45 to 65, especially for people who have Alzheimer’s disease in their family. , the possibility of them contracting this disease increases; Because APP and MAPT genes are activated in these people at the age of 45 to 65 years.

The presenter of the project stated that APP and MAPT genes are the coding agents of beta-amyloids and tau protein, and pointed out: the use of this complementary drug causes the expression of these genes to decrease or inhibits the expression of these
genes, and as a result of this Proteins that act on neurons prevent them from coding

Results of animal studies

He mentioned the phase of animal studies as one of the other research parts of this project and said: In Alzheimer’s disease, due to the production of amyloid plaques and its deposition on neuronal cells, on the one hand, as well as the hyperphosphorylation of tau protein and the creation of toxicity inside neuronal cells, one of the factors It is important and key in Alzheimer’s disease. In this research phase, we expressed the APP gene by injecting manganese nano powder into rats, which caused an increase in the incidence of this disease in them, and we treated them with different doses of this drug and observed that in the rats, in the process of 14 to 21 days The expression of these genes was decreased

According to this researcher, the APP gene is the precursor of beta-amyloid. Beta-amyloid is the cause of Alzheimer’s and in people with Alzheimer’s, this gene has the highest level of expression, and the expression of this gene decreases with the use of drugs

Bayhaghi emphasized: Also, this drug reduces the expression of the MAPT gene, which is responsible for the production of tau protein. Tau protein is abundantly found in neurons of the central nervous system and to a lesser extent in astrocytes and oligodendrocytes. Tau proteins that have lost their function in stabilizing microtubules are the main cause of dementia-related diseases such as Alzheimer’s and Parkinson’s

Supplement use for healthy people

While stating that this supplement prevents the occurrence of Alzheimer’s disease, he recommended that people with a history of Alzheimer’s disease in the family should take this supplement and said: If people take this supplement in the form of medicated candy, it is as if people Patients with this disease should use this candy twice a day. The candy should be sucked for 5 to 7 minutes, and during this time, nano medicinal substances will be slowly released in the body.

Bayhaghi stated that the syrup form of this drug should be taken twice a day at the rate of 5 cc and added: People who want to take this drug for prevention should take this drug twice a week.

This researcher of Bo Ali Research Institute of Mashhad University of Medical Sciences emphasized: This drug is undergoing the necessary permits from the Food and Drug Organization.